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Paper - I
(Basic Sciences)

Unit - I : Microbiology

1. Microbiology classification, monophology, characterisation and isolation
2. Metabolism, Growth
3. Environmental effect
4. Axenic mixed culture concept - interaction and ecosystem model.

Unit - II : Immunology And Virology

1. Immunity and antibodies,
2. Immuno regulations
3. Molecular variability of antibody specificity
4. Immunological techniques - immuno electrophoresis - etc.,
5. Ultrastructure of viruses,
6. DNA and RNA viruses
7. Viral infections
8. Retroviruses
9. Interferons - mechanism of action ect.,

Unit - III : Cell And Tissue Culture

1. Different cell lines - characterisation and maintenance
2. Hybridoma technology
3. Tissue organisation
4. Mechanical factors analysis.

Unit - IV : Genetics And Molecular Biology

1. Chromosome, Plasmids
2. Genetic mapping
3. Mandelian and Non-Mandelian Principles
4. Genetics and Society
5. DNA and RNA
6. Coding system - genetic regulation
7. Operon - promoter - repressor relation
8. Eucaryotic regulation

Unit - V : Applied Genetics

1. R-DNA Protoplast Fusion
2. Role of d NTPs
3. In vitro DNA Synthesis
4. Site - directed mutagenesis - PCR, SSDNA and DSDNA Cloning
5. Vectors - Properties etc., Restriction mapping
6. c DNA and Genomic library
7. RFLP

Unit - VI : Physiology

1. Special Sensery mechanisms
2. Body fluids - Properties etc.,
3. Histological studies of organs and tissues

Unit - VII : Biochemistry And Biophysics

1. Supra molecular assemblies
2. Biomembrane
3. Metabolism
4. Bioenergetis
5. Biopolymer structure and function
6. Irreversible thermodynamics in biology

Unit - VIII : Bio-Inorganic & Bio-Organic Chemistry

1. Metalloproteins
2. Transition metal in biological reactions
3. Role of chelating agents and metals in medicine
4. Trace elements absorbtion
5. Transport and tissue storage
6. Carbohydrate biopolymers
7. Glycoproteins

Unit - IX : Membrane Science

1. Analysis of membrane assymetry
2. Lipid - protein interactions
3. Lipid components in membranes
4. Lipsomes
5. Membrane potentials
6. Membrane bound enzymes, transport and receptors

Unit - X : Bio Analytical Techniques

1. IR, NMR, Mass spectrometry principles
2. Ion beam technique
3. Time resolved fluorescenes spectroscopy
4. X-ray crystallography
5. Microscopy
6. Spectrometry, fluorimetry etc.

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Paper - II
(Applied & Engineering Subjects)

Unit - I : Bio-Process Technology

1. Energy, Mass and momentum transfer
2. Material and enrgy balances
3. Upstreaming operations - Sterilization, air filter design
4. Biological process principle
5. Statistical optimisation techniques in biological system - Plackett - Burman, CCD, ANOVA analysis and contour interpretation.
6. Cellualar and enzymatic reactions.

Unit - II : Protein Engineering And Bio-Informatics

1. Protein data bank
2. Protein structures; structure & function analysis
3. Domain analysis in proteins
4. Protein design, protein sequencing

Unit - III : Bio-Conversion And Fermentation Technology

1. Bioconversion of starch, cellulose, corn
2. Bioenrgy production
3. Industrial applications of cells and enzymes
4. Biopolymer design and synthesis
5. Fermentation technologies for waste stabilization and bio-product synthesis.
6. Antibiotics and steroid fermentation

Unit - IV : Downstream Technology

1. Flocculation, Coagulation, Centrifugation
2. Equilibrium (stage) processes - distillation and liquid - liquid extraction.
3. Chromatography - GPC, Ion-exchange, affinity
4. Separation of intracellular products
5. Membrane Separations - Reverse Osmosis, ultrafiltration, Microfiltration
6. Aqueous two phase system
7. Supercritical fluid extraction.

Unit - V : Kinetics And Thermodynamics In Bio-Processes

1. Moinod's equation - generalized Monod' equaiton
2. Structured models
3. Application of Arrhenius equation
4. Stability analysis of cellular and enzymati porcesses - D*, DS*, DH* calculation.

Unit - VI : Bio-Reactors

1. Basic principles of bioreactors
2. Configuration and their analysis
3. Non-ideal effects
4. Control of bioreactor
5. Bioreactor modelling and stability analysis
6. Mechanical design concept

Unit - VII : Process Design And Scale-Up

1. Flow sheet analysis
2. Identification of crucial factors in processes
3. Computer - aided design
4. Scale-up criteria - k,a, power number etc.
5. Economic analysis for process scale-up and scale-down

Unit - VIII : Food Technology

1. Components in food
2. Basal metabolic rate
3. Long term preservation - canning, freeze drying, sprary drying
4. UHT concept and pasteurization

Unit - IX : Pharmaceutical Science And Engineering

1. Pharmacekinetics
2. Major unit operations in pharmaceutical processing of antibiotics., life saving drugs and their formulation.
3. Concept of LD50.

Unit - X : Laboratory Hygiene And Environment Safety

1. Biosafety regulations
2. Handling of genetically enginured organisms
3. Disposal of radioactive components and otehr health hazard substances
4. Public health and pollution problems
5. Waste management, recycling